Chronic lysosome damage boosts interferon responses to Palbociclib dependent upon the mitochondrion
Mihaela Božić, Tian En Lim, Carla Salomo-Coll, Arianna Karageorgiou, Alain J. Kemp, Katie Winnington-Ingram, Laura C. Murphy, Ashish Dhir, Ann P. Wheeler, Natalia Jiménez-Moreno, Simon Wilkinson
The paper shows chronic lysosome damage from Palbociclib treatment in cancer cells triggers interferon responses via mitochondrial nucleic acid release, dependent on lysosome-mitochondrion contacts.
bioRxiv · Mar 13, 2025 · PreprintCell Biology