Dysproteostasis primes pancreatic epithelial state changes in KRAS-mediated oncogenesis
Carla Salomo-Coll, Marisa Di Monaco, Jocelyn Holkham, Matthew Denman Smith, Morwenna Muir, Philippe Emmanuel Gautier, Hywel Dunn-Davies, Xiaozhong Zheng, Roopesh Krishnankutty, Alain J. Kemp, Katie Winnington-Ingram, Alex von Kriegsheim, Jennifer P. Morton, Natalia Jiménez-Moreno, Damian J. Mole, Simon Wilkinson
This study shows that proteostatic failure in ER-phagy, driven by Kras, leads to protein aggregates that prime acinar-ductal metaplasia and pancreatic cancer.
Developmental Cell · Aug 15, 2025Peer-reviewedCancer Biology