Simon Wilkinson

The paper identifies ER-liquid condensates that sequester FAM134B/C and RhoA, affecting cell morphology and cancer invasion.

The paper introduces a pipeline for single-cell proteomics analysis that addresses challenges in data processing and annotation using context-aware methods and large language models.

This study shows that proteostatic failure in ER-phagy, driven by Kras, leads to protein aggregates that prime acinar-ductal metaplasia and pancreatic cancer.

This paper develops a method to perform single-cell proteomics on preserved tissues, expanding its applicability by overcoming sample preservation challenges.

The paper shows chronic lysosome damage from Palbociclib treatment in cancer cells triggers interferon responses via mitochondrial nucleic acid release, dependent on lysosome-mitochondrion contacts.