Carla Salomo-Coll

A Context-Aware Single-Cell Proteomics Analysis pipeline.

The paper introduces a pipeline for single-cell proteomics analysis that addresses challenges in data processing and annotation using context-aware methods and large language models.

Dysproteostasis primes pancreatic epithelial state changes in KRAS-mediated oncogenesis

This study shows that proteostatic failure in ER-phagy, driven by Kras, leads to protein aggregates that prime acinar-ductal metaplasia and pancreatic cancer.

Chronic lysosome damage boosts interferon responses to Palbociclib dependent upon the mitochondrion

The paper shows chronic lysosome damage from Palbociclib treatment in cancer cells triggers interferon responses via mitochondrial nucleic acid release, dependent on lysosome-mitochondrion contacts.