Tim J. Cooper

Localised negative feedback shapes genome-wide patterning of meiotic DNA breaks

The paper models how Tel1-mediated feedback shapes Spo11-DSB formation in yeast, showing local inhibition leads to genome-wide DSB redistribution.

Mismatch repair disturbs meiotic class I crossover control

The paper shows that mismatch repair (MMR) suppresses meiotic class I crossovers (COs) at regions of high sequence divergence in yeast, linking MMR to CO distribution and speciation.

Concerted cutting by Spo11 illuminates DNA break mechanisms and initiates gap repair during meiosis

The paper shows that DNA double-strand breaks (DSBs) during meiosis often occur in clusters with periodic spacing, challenging the idea that DSBs are isolated events.

A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome

The paper maps Top2-linked DNA breaks with nucleotide resolution in yeast and human genomes, revealing distinct activity fractions and sequence influences on cleavage.

Separable roles of the DNA damage response kinase Mec1(ATR) and its activator Rad24(RAD17) within the regulation of meiotic recombination

This study investigates the distinct roles of Mec1 and Rad24 in meiotic recombination, showing that Mec1 affects DSB trans-interference and CO pathway distribution, while Rad24 influences interference through CO number reduction.