Jon Alexander Harper

Transcription directs Holliday junction branch migration

The paper shows that Top3 activity moves Holliday junctions from Spo11 hotspots to convergent transcription sites, where crossover resolution occurs during meiosis.

Evidence for sexual antagonism and antagonistic pleiotropy in the maintenance of late onset Alzheimer's disease alleles

The paper investigates the role of sexual antagonism and antagonistic pleiotropy in maintaining late-onset Alzheimer's disease alleles, finding evidence of sexually dimorphic genetic effects and an inverse relationship with cancer risk.

Localised negative feedback shapes genome-wide patterning of meiotic DNA breaks

The paper models how Tel1-mediated feedback shapes Spo11-DSB formation in yeast, showing local inhibition leads to genome-wide DSB redistribution.

The Balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells

This study shows that the balance between B55α and Greatwall expression levels determines cancer cell sensitivity to Greatwall inhibition.

Systematic review reveals multiple sexually antagonistic polymorphisms affecting human disease and complex traits

This study reviews evidence for sexually antagonistic polymorphisms in humans and finds 51 genes with sex-opposite effects, though none are explicitly labeled as such.