William H. Gittens

The paper shows that Top3 activity moves Holliday junctions from Spo11 hotspots to convergent transcription sites, where crossover resolution occurs during meiosis.

The paper models how Tel1-mediated feedback shapes Spo11-DSB formation in yeast, showing local inhibition leads to genome-wide DSB redistribution.

The paper shows that extending meiotic prophase reduces DSB clustering by allowing chromosomal domains to reach similar Spo11-DSB potential.

The paper introduces CC-seq, a method to map Spo11 DNA double-strand breaks with nucleotide-resolution in S. cerevisiae meiotic cells.

The paper maps Top2-linked DNA breaks with nucleotide resolution in yeast and human genomes, revealing distinct activity fractions and sequence influences on cleavage.