Author

Todd C. Chappell

Tufts University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Organism:yeast· 1

Frequent Co-Authors

Nikhil U. NairiD· 3 shared Vikas D. TrivediiD· 2 shared Angela TarveriD· 1 shared Anuj ShettyiD· 1 shared Arushi Kalia· 1 shared Daniel SellersiD· 1 shared Jan‐Fang ChengiD· 1 shared Jessica A. LeeiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersSynthetic Biology

Nikhil U. NairORCID

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3 papers

Recent·Most cited

Advancing protein display on bacterial spores through an extensive survey of coat components

Todd C. Chappell, Trevor B. Nicks, Jessica A. Lee, Jan‐Fang Cheng, Angela Tarver, Arushi Kalia, Nikhil U. Nair

This study evaluates 33 spore proteins for enzyme display on Bacillus subtilis spores, identifies SscA as the most effective carrier, and highlights challenges in predicting fusion compatibility.

JACS Au · Jun 11, 2026Peer-reviewedSynthetic Biology

Towards universal synthetic heterotrophy using a metabolic coordinator

Sean F. Sullivan, Anuj Shetty, Tharun Bharadwaj, Naveen Banchallihundi Krishna, Vikas D. Trivedi, Venkatesh Endalur Gopinarayanan, Todd C. Chappell, Daniel Sellers, R. Pravin Kumar, Nikhil U. Nair

This paper introduces a metabolic coordinator, Gal3pMC, that enables efficient activation of the GAL regulon across diverse substrates, improving growth rates and substrate utilization in yeast.

Metabolic Engineering · Sep 1, 2023Peer-reviewedSynthetic Biology

Cheating the cheater: Suppressing false positive enrichment during biosensor-guided biocatalyst engineering

Vikas D. Trivedi, Karishma Mohan, Todd C. Chappell, Zachary J. S. Mays, Nikhil U. Nair

The paper addresses false positive enrichment in biosensor-guided biocatalyst engineering by desensitizing biosensors and using orthogonal pre-screens to reduce cheater cells during FACS.

ACS Synthetic Biology · Dec 16, 2021Peer-reviewedSynthetic Biology