BIN1 expression in the presynaptic compartment leads to isoform-specific synaptotoxicity
Erwan Lambert, Carla Gelle, Valentin Leclerc, Alejandra Freire‐Regatillo, Nicolas Barois, Tommy Malfoi, Xavier Hermant, Florie Demiautte, Frank Lafont, Philippe Amouyel, K. Blary, Sabine Kuenen, Chloé Najdek, Patrik Verstreken, Dolores Siedlecki‐Wullich, , Pierre Dourlen
This study shows that BIN1 isoform 1 expression in the presynaptic compartment causes synaptotoxicity, leading to synaptic loss and structural changes in Drosophila and rat models.
bioRxiv · Aug 11, 2025 · PreprintNeuroscience