Sensitisation of colonic nociceptors by TNFα is dependent on TNFR1 expression and p38 MAPK activity
Katie H. Barker, James P. Higham, Luke A. Pattison, Toni S. Taylor, Iain P. Chessell, Fraser Welsh, Ewan St. John Smith, David Colin Bulmer
This study shows TNFα sensitizes colonic nociceptors via TNFR1 and p38 MAPK, enhancing responses to capsaicin and noxious distension.
The Journal of Physiology · Jul 1, 2022Peer-reviewedNeuroscience