James R.F. Hockley

The paper investigates how cromolyn, a GPR35 agonist, inhibits PGE2-induced TRPV1 sensitization in sensory neurons, supporting GPR35 as an anti-nociceptive target.

This study identifies GPR68 as a mediator of acid-induced colonic nociception through genetic and pharmacological approaches in mice.

This study shows TRPV4 activation in the colon increases afferent activity via mucosal release of ATP and glutamate, suggesting a target for visceral pain treatment.

The paper identifies a genetic variant in KCNG4 associated with increased labor pain by altering KV6.4 function in uterine nociceptors.

This study investigates acid and inflammatory sensitivity of colonic afferent nerves in naked mole-rats compared to mice, showing differential responses to acid and bradykinin.

This study shows galanin inhibits colonic afferent responses to mechanical and inflammatory stimuli via GalR1, with effects absent in inflamed tissue.

This study shows that acute knee inflammation in mice sensitizes sensory neurons and reduces digging behavior, mediated by TRPV1 receptor upregulation.