Author
AstraZeneca (United Kingdom)ORCID 0009-0003-8197-1000Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Luke W Paine, Rohit Gupta, James P. Higham…·David Colin Bulmer
This study identifies GPR68 as a mediator of acid-induced colonic nociception through genetic and pharmacological approaches in mice.
Luke W Paine, James P. Higham, Katie H. Barker…·David Colin Bulmer
The paper identifies IL-17's role in enhancing pain sensitivity in the gut via PI3K-dependent mechanisms in ulcerative colitis.
Rebecca H. Rickman, Luke A. Pattison, Lanhui Qiu…·Ewan St. John Smith
This study shows that sphingomyelin 34:1 induces inflammatory pain and neuronal hyperexcitability in mice with osteoarthritis.
Michelle Y. Meng, Luke W Paine, David Sagnat…·David Colin Bulmer
This study shows TRPV4 activation in the colon increases afferent activity via mucosal release of ATP and glutamate, suggesting a target for visceral pain treatment.
Rayan Haroun, Samuel J. Gossage, Federico Iseppon…·John N. Wood
This study evaluates three potential treatments for cancer-induced bone pain in mice, finding that dual inhibition of NGF and TNF significantly reduces pain-related behaviors.
Katie H. Barker, James P. Higham, Luke A. Pattison…·David Colin Bulmer
This study shows TNFα sensitizes colonic nociceptors via TNFR1 and p38 MAPK, enhancing responses to capsaicin and noxious distension.