Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer's disease
Yifei Cai, Jean E. Kanyo, Rashaun S. Wilson, Shveta Bathla, Pablo Leal Cardozo, Лей Тонг, Shanshan Qin, Lukas A. Fuentes, Iguaracy Pinheiro‐de‐Sousa, Tram Huynh, Liyuan Sun, Mohammad Shahid Mansuri, Zichen Tian, Hao-Ran Gan, Amber Braker, , Jaime Grutzendler
The paper uses subcellular proteomics and iPSC models to identify mTOR pathway activation in axonal spheroids and show its reversible role in Alzheimer's disease pathology.
Nature Aging · Mar 10, 2025Peer-reviewedNeuroscience