Angus Clark Nairn

Protracted abstinence from heroin, but not cocaine, is associated with profound medial prefrontal cortex synaptic bioenergetic remodeling and lasting neural hypofunction

The paper identifies synaptic bioenergetic remodeling in the mPFC after heroin abstinence, but not cocaine, and links it to relapse vulnerability.

mPFC Synaptosome Proteomics Reveals Novel Pathways and Muscarinic Receptor Changes in a Learned Helplessness Mouse Model

The paper identifies proteomic changes in mPFC synaptosomes of mice exposed to inescapable stress, highlighting muscarinic receptor alterations and signaling pathway disruptions linked to depression.

Dysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation.

This study identifies age-related calcium signaling dysregulation in macaque entorhinal cortex linked to early tau hyperphosphorylation, suggesting a mechanism for Alzheimer's disease initiation.

Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer's disease

The paper uses subcellular proteomics and iPSC models to identify mTOR pathway activation in axonal spheroids and show its reversible role in Alzheimer's disease pathology.

Operant training for highly palatable food alters translating mRNA in nucleus accumbens D2 neurons and reveals a modulatory role of Neurochondrin

This study shows that operant training with highly palatable food alters translating mRNA in NAc D2 neurons and that Ncdn downregulation modulates satiety-sensitive feeding behavior.

Human-specific features and developmental dynamics of the brain N-glycome

The paper characterizes the evolution of the brain N-glycome across primates, finding increased complexity and human-specific sialic acid linkage changes.

Differential Effects of Cocaine and Morphine on the Diurnal Regulation of the Mouse Nucleus Accumbens Proteome

This study examines how cocaine and morphine affect diurnal proteome rhythms in the mouse nucleus accumbens, revealing distinct pathway alterations.

Adult-specific Reelin expression alters striatal neuronal organization. Implications for neuropsychiatric disorders.

This study investigates how adult-specific Reelin expression affects striatal neuronal organization and its implications for neuropsychiatric disorders using mouse models.

PP1β opposes classic PP1 function, inhibiting spine maturation and promoting LTP

This study identifies PP1β as a regulator of synaptic plasticity and memory, opposing the role of classic PP1 by promoting spine maturation and LTP.

PP1 inhibitor-2 promotes PP1γ positive regulation of synaptic transmission

The paper shows that I-2 promotes PP1γ positive regulation of synaptic transmission in hippocampal neurons through enhanced interaction with neurabin.

Pathogenic MAST3 variants in the STK domain are associated with epilepsy

The paper identifies de novo MAST3 variants in individuals with epilepsy, showing they may confer gain-of-function and are restricted to excitatory neurons in the cortex.

GSAP regulates mitochondrial function through the Mitochondria-associated ER membrane in the pathogenesis of Alzheimer's disease

This study identifies GSAP's role in Alzheimer's disease by showing it regulates mitochondrial function through the MAM and lipid homeostasis, with a SNP linked to increased AD risk.

Translational profiling of mouse dopaminoceptive neurons reveals a role of PGE2 in dorsal striatum

The paper identifies translational and splicing differences in dopaminoceptive neurons and highlights PGE2's role in enhancing D2 dopamine receptor function in the dorsal striatum.

Multiplexed fractionated proteomics reveals synaptic factors associated with cognitive resilience in Alzheimer's Disease

The paper uses multiplexed proteomics to identify synaptic factors linked to cognitive resilience in Alzheimer's Disease by analyzing brain tissue from individuals with varying pathology and cognitive outcomes.