Author

Zichen Tian

Mayo Clinic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Amber Braker· 1 shared Angus Clark NairniD· 1 shared Anita J HuttneriD· 1 shared Brandon A. WilbanksiD· 1 shared Caroline D. DohertyiD· 1 shared Danielle M. BurgenskeiD· 1 shared Evangelia PetsalakiiD· 1 shared Hao-Ran Gan· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperNeuroscience

Amber Braker

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2 papers

Recent·Most cited

In Vivo Selection of anti-glioblastoma DNA aptamer-drug conjugates in an orthotopic patient-derived xenograft model

Caroline D. Doherty, Sonia Jain, Lauren L. Ott, Katie Bakken, Brandon A. Wilbanks, Danielle M. Burgenske, Keenan S. Pearson, Jessica I. G. Griffith, Zichen Tian, Jeffrey A. Meridew, Saigopalakrishna S. Yerneni, William F. Elmquist, Jann Nagina Sarkaria, Louis James Maher III

This study develops and tests DNA aptamer-drug conjugates (ApDCs) for glioblastoma treatment using an in vivo SELEX approach in a patient-derived xenograft model.

NAR Cancer · Jul 27, 2026Peer-reviewedCancer Biology

Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer's disease

Yifei Cai, Jean E. Kanyo, Rashaun S. Wilson, Shveta Bathla, Pablo Leal Cardozo, Лей Тонг, Shanshan Qin, Lukas A. Fuentes, Iguaracy Pinheiro‐de‐Sousa, Tram Huynh, Liyuan Sun, Mohammad Shahid Mansuri, Zichen Tian, Hao-Ran Gan, Amber Braker, , Jaime Grutzendler

The paper uses subcellular proteomics and iPSC models to identify mTOR pathway activation in axonal spheroids and show its reversible role in Alzheimer's disease pathology.

Nature Aging · Mar 10, 2025Peer-reviewedNeuroscience