Armoring STEAP1 CAR T cells with IL-18 potentiates antitumor activity in Ewing sarcoma
Vipul Bhatia, Annabelle Tsao, Truman Chong, Peter P. Challita, Keke Liang, Erolcan Sayar, Jiaoti Huang, Elizabeth R. Lawlor, Michael C. Haffner, Behnam Nabet, John K. Lee
This study shows that IL-18-armored STEAP1 CAR T cells effectively treat Ewing sarcoma with reduced dose and improved efficacy.
bioRxiv · Dec 11, 2025 · PreprintCancer Biology