Collagen targeting IL-12 combined with Doxorubicin enhances the anti-tumor effect against osteosarcoma
Takumi Matsuo, Laurine Noblecourt, Pooja Kaur, Chuyi Wang, Po-Chuan Chiu, Koichi Sasaki, Takanatsu Hosokawa, Charanjit Singh, Adrian Lärkeryd, Tomonori Ueno, Kazunori Mizuno, Anguraj Sadanandam, Paul H. Huang, Jun Ishihara
This study combines collagen-targeted IL-12 with doxorubicin to improve anti-tumor effects in osteosarcoma by enhancing tumor accumulation and immune activation.
Journal of Controlled Release · Sep 26, 2026Peer-reviewedBioengineering