A human cell model of cardiac pathophysiological valvulogenesis
Tui Néri, Emilye Hiriart, Patrick Piet Van Vliet, Emilie Faure, Russell A. Norris, Batoul Farhat, Julie Lefrancois, Thomas Moore‐Morris, Stéphane Zaffran, Randolph S. Faustino, Alexander C. Zambon, Yukiko Sugi, Jean‐Pierre Desvignes, David Salgado, Robert A. Levine, , Michel Pucéat
This paper develops a human pluripotent stem cell model to study valvulogenesis and disease, showing it can recapitulate valve development and disease traits like mitral valve prolapse.
bioRxiv · Aug 22, 2018 · PreprintDevelopmental Biology