Direct cell reprogramming by a designed agonist inducing HER2-FGFR proximity
Riya Keshri, Marc Expòsit, Mohamad H. Abedi, Derrick R. Hicks, Zachary Foreman, Ashish Phal, Yen Chian Lim, Philip Barrett, Catherine M Sniezek, Jinlong Lin, Thomas Schlichthaerle, Alexander Robinson, Damien Detraux, Tung Chan Ching, Keija Wu, , Hannele Ruohola‐Baker
This paper designs a synthetic ligand, H2F, that induces HER2-FGFR proximity to reprogram fibroblasts into myogenic cells and promote myogenic regeneration.
bioRxiv · Oct 12, 2025 · PreprintBiochemistry