Cancer-associated hypersialylated MUC1 drives the differentiation of monocytes into macrophages with a pathogenic phenotype
R. Beatson, R. Graham, F. Grundland Freile, D. Cozzetto, S. Kannambath, E. Pfeifer, N. Woodman, J. Owen, R. Nuamah, U. Mandel, S. Pinder, C. Gillett, T. Noll, I. Bouybayoune, J. Taylor-Papadimitriou, J. M. Burchell
This study identifies MUC1-ST as a driver of monocyte differentiation into pathogenic macrophages in the tumor microenvironment, associated with poor breast cancer prognosis.
bioRxiv · May 6, 2020Cancer Biology