Author

U. Uche

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. L. Szymczak-Workman· 2 shared L. P. Kane· 2 shared A. Chang· 1 shared A. J. Heidersbach· 1 shared A. Piccirillo· 1 shared A. Wallace· 1 shared A.-J. Tong· 1 shared B. Haley· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

A. L. Szymczak-Workman

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Downregulation of PIK3IP1/TrIP on T cells is controlled by TCR signal strength, PKC, and metalloprotease-mediated cleavage

B. M. Murter, S. C. Robinson, H. Banerjee, L. Lau, U. Uche, A. L. Szymczak-Workman, L. P. Kane

This study identifies mechanisms controlling TrIP downregulation on T cells, showing it depends on TCR signal strength, PKC, and ADAM proteases.

bioRxiv · Apr 29, 2024Cell Biology

Discovery of prevalent, clinically actionable tumor neoepitopes via integrated biochemical and cell-based platforms

H. Gurung, A. J. Heidersbach, M. Darwish, P. Chan, J. Li, M. Beresini, O. Zill, A. Wallace, A.-J. Tong, D. Hascall, E. Torres, A. Chang, K. Lou, Y. Abdolazimi, U. Uche, , C. M. Rose

The paper identifies 84 clinically relevant neoepitope-HLA pairs from 37 shared cancer neoantigens using a combination of biochemical assays and computational methods.

bioRxiv · Oct 27, 2022 · PreprintCancer Biology

PIK3IP1/TrIP restricts activation of T cells through inhibition of PI3K/Akt

U. Uche, A. L. Szymczak-Workman, S. Grebinoski, A. Piccirillo, L. M. D'Cruz, L. P. Kane

This study identifies TrIP as a negative regulator of T cell activation by inhibiting PI3K, showing its role in immune response and potential as a therapeutic target.

bioRxiv · Nov 6, 2017Immunology

U. Uche · henhao