Atxn2-CAG100-knock-in affects mouse lifespan and vestibulo-cerebellar function via neural disconnection
Melanie Vanessa Halbach, Nesli-Ece Şen, Júlia Canet-Pons, Bram W. Kuppens, Mandy Segers, Martijn Schonewille, Ewa Rollmann, Kay Seidel, Udo Rüb, David Meierhofer, Michel Guy André Mittelbronn, Patrick N. Harter, Chris I. De Zeeuw, Luis Enrique Almaguer-Mederos, Suzana Gispert, , Georg W. J. Auburger
This paper describes a novel SCA2 mouse model with CAG100 expansion in Atxn2, showing reduced lifespan and vestibulo-cerebellar dysfunction due to axon-myelin disconnection.
bioRxiv · Jun 4, 2018 · PreprintNeuroscience