Author

Melanie Vanessa Halbach

Goethe University Frankfurt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

Georg W. J. AuburgeriD· 3 shared Júlia Canet-PonsiD· 3 shared Luis Enrique Almaguer-MederosiD· 3 shared Nesli-Ece Şen· 3 shared Suzana Gispert· 3 shared Aleksandar Arsović· 2 shared Chris I. De ZeeuwiD· 2 shared David MeierhoferiD· 2 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Georg W. J. AuburgerORCID

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Author profile →

3 papers

Recent·Most cited

ATXN2 polyglutamine expansion impairs QKI-dependent alternative splicing and oligodendrocyte maintenance

Nesli-Ece Şen, Jaime Eugenin von Bernhardi, Jubril Olamide Adeyemi, Aleksandar Arsović, Júlia Canet-Pons, Antonio J. Miralles, Jana Key, Lorenzo Bina, Vincenzo Romano, Meike Fellenz, Matthias Pietzke, Melanie Vanessa Halbach, Kay Seidel, Elif Fidan, Zeynep Ece Kaya Güleç, , Georg W. J. Auburger

This study shows that ATXN2 polyglutamine expansion impairs QKI-dependent alternative splicing and oligodendrocyte maintenance in a mouse model of SCA2.

bioRxiv · Aug 8, 2025 · PreprintNeuroscience

Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression

Júlia Canet-Pons, Nesli-Ece Şen, Aleksandar Arsović, Luis Enrique Almaguer-Mederos, Melanie Vanessa Halbach, Jana Key, Claudia Döring, Anja Kerksiek, Gina Picchiarelli, Raphaelle Cassel, Frédérique René, Stéphane Dieterle, Nina V. Fuchs, Renate König, Luc Dupuis, , Georg W. J. Auburger

This study examines an SCA2 mouse model to identify molecular mechanisms of spinal cord pathology, finding progressive TDP43 aggregation and cholesterol biosynthesis suppression.

Neurobiology of Disease · Feb 10, 2021Peer-reviewedNeuroscience

Atxn2-CAG100-knock-in affects mouse lifespan and vestibulo-cerebellar function via neural disconnection

Melanie Vanessa Halbach, Nesli-Ece Şen, Júlia Canet-Pons, Bram W. Kuppens, Mandy Segers, Martijn Schonewille, Ewa Rollmann, Kay Seidel, Udo Rüb, David Meierhofer, Michel Guy André Mittelbronn, Patrick N. Harter, Chris I. De Zeeuw, Luis Enrique Almaguer-Mederos, Suzana Gispert, , Georg W. J. Auburger

This paper describes a novel SCA2 mouse model with CAG100 expansion in Atxn2, showing reduced lifespan and vestibulo-cerebellar dysfunction due to axon-myelin disconnection.

bioRxiv · Jun 4, 2018 · PreprintNeuroscience