Martijn Schonewille

Purkinje cell intrinsic activity shapes cerebellar development and function

This study shows that Purkinje cell intrinsic activity before synaptic maturation is critical for dendrite growth, connectivity, and cerebellar function, with early disruptions causing severe morphological and functional defects.

PP2B-dependent cerebellar plasticity sets the amplitude of an innate reflex during juvenile development

This study shows that early disruption of cerebellar plasticity affects the setpoint of the vestibulo-ocular reflex (VOR), while adult-onset disruption only impacts its adaptation.

cAMP-EPAC-PKCε-RIM1α signaling regulates presynaptic long-term potentiation and motor learning

This study identifies a novel cAMP-EPAC-PKCε-RIM1α signaling cascade that regulates presynaptic long-term potentiation and motor learning in the cerebellum.

Tsc1 haploinsufficiency leads to Pax2 dysregulation in the developing murine cerebellum

This paper investigates how Tsc1 haploinsufficiency affects cerebellar development in mice, finding dysregulated Pax2 expression and mTOR pathway changes linked to ASD-like phenotypes.

NMDARs expressed in Granule Cells are involved in cerebellar plasticity and motor learning

The paper shows that presynaptic NMDARs in granule cells are essential for bidirectional synaptic plasticity and motor learning in adult rodents.

TRPC3 is essential for functional heterogeneity of cerebellar Purkinje cells

This study shows TRPC3 is essential for functional heterogeneity in cerebellar Purkinje cells by affecting simple and complex spike activity and behavior related to specific modules.

Atxn2-CAG100-knock-in affects mouse lifespan and vestibulo-cerebellar function via neural disconnection

This paper describes a novel SCA2 mouse model with CAG100 expansion in Atxn2, showing reduced lifespan and vestibulo-cerebellar dysfunction due to axon-myelin disconnection.