DNA origami demonstrate the unique stimulatory power of single pMHCs as T-cell antigens
J. Hellmeier, R. Platzer, A. S. Eklund, T. Schlichthaerle, A. Karner, V. Motsch, E. Kurz, V. Bamieh, M. Brameshuber, J. Preiner, R. Jungmann, H. Stockinger, G. J. Schuetz, J. B. Huppa, E. Sevcsik
The paper demonstrates that single pMHCs can robustly stimulate T-cells as isolated entities, identifying the minimal requirements for effective TCR-triggering.
Proceedings of the National Academy of Sciences · Jan 19, 2021Peer-reviewedBiophysics