PLA2G15 is a Lysosomal BMP Hydrolase and Its Targeting Ameliorates Lysosomal Disease
K. Nyame, J. Xiong, A. de Jong, H. N. Alsohybe, M. Raaben, G. Hartmann, J. A. Simcox, V. Blomen, M. Abu-Remaileh, I. V. Pena, R. de Miguel, T. R. Brummelkamp, S. M. B. Nijman
This study identifies PLA2G15 as a lysosomal BMP hydrolase and shows its targeting improves lysosomal disease symptoms in NPC1 models.
bioRxiv · Jun 7, 2024Cell Biology