Author

J. A. Simcox

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Caldwell· 1 shared A. de Jong· 1 shared A. J. Smith· 1 shared A. K. Bartlett· 1 shared A. R. Chevalier· 1 shared B. F. Pfleger· 1 shared D. Amador-Noguez· 1 shared D. B. Khana· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

A. Caldwell

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Author profile →

2 papers

Recent·Most cited

PLA2G15 is a Lysosomal BMP Hydrolase and Its Targeting Ameliorates Lysosomal Disease

K. Nyame, J. Xiong, A. de Jong, H. N. Alsohybe, M. Raaben, G. Hartmann, J. A. Simcox, V. Blomen, M. Abu-Remaileh, I. V. Pena, R. de Miguel, T. R. Brummelkamp, S. M. B. Nijman

This study identifies PLA2G15 as a lysosomal BMP hydrolase and shows its targeting improves lysosomal disease symptoms in NPC1 models.

bioRxiv · Jun 7, 2024Cell Biology

ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism

E. H. Rashan, A. K. Bartlett, D. B. Khana, J. Zhang, R. Jain, A. J. Smith, Z. N. Baker, T. Cook, A. Caldwell, A. R. Chevalier, B. F. Pfleger, P. Yuan, D. Amador-Noguez, J. A. Simcox, D. J. Pagliarini

This study identifies ACAD10 and ACAD11 as enzymes critical for metabolizing 4-hydroxy fatty acids in mammals, revealing their unique mechanisms and subcellular localization.

bioRxiv · Jan 9, 2024Biochemistry