The SPPL3-defined glycosphingolipid repertoire regulates immune responses by improving HLA class I access
M. L. M. Jongsma, M. Raaben, A. A. de Waard, T. Zhang, B. Cabukusta, R. Platzer, V. A. Blomen, A. Xagara, T. Verkerk, S. Bliss, L. Janssen, E. Stickel, S. Holst, R. Plomp, A. Mulder, , R. M. Spaapen
The paper identifies a glycosphingolipid (GSL) signature that inhibits HLA-I antigen presentation and shows its reversal by clinically approved drugs.
bioRxiv · Sep 26, 2020Immunology