Author

M. D. Wilson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:chromatin & epigenetic regulation· 4 Organism:human· 3 Approach:microscopy & imaging analysis· 2 Approach:statistical model· 2 Assay:structural biology· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

G. Deak· 2 shared H. Burdett· 2 shared H. Wapenaar· 2 shared J. A. Watson· 2 shared M. R. Taylor· 2 shared A. Basle· 1 shared A. Costa· 1 shared A. Das· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

G. Deak

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Author profile →

6 papers

Recent·Most cited

The N-terminal region of DNMT3A combines multiple chromatin reading motifs to guide recruitment.

H. Wapenaar, G. Clifford, W. Rolls, H. Burdett, Y. Zhang, G. Deak, J. Zou, M. R. Taylor, J. Mills, J. A. Watson, D. Kumar, A. Das, D. Valsakumar, J. Bramham, P. Voigt, M. D. Wilson

This study identifies the N-terminal region of DNMT3A as containing multiple chromatin-binding motifs that mediate recruitment through interactions with nucleosomes and ubiquitylated histone H2AK119.

bioRxiv · Oct 29, 2023Biochemistry

Histone divergence in Trypanosoma brucei results in unique alterations to nucleosome structure

G. Deak, H. Wapenaar, G. Sandoval, R. Chen, M. R. Taylor, H. Burdett, J. A. Watson, M. W. Tuijtel, S. Webb, M. D. Wilson

This study characterizes the structure of nucleosome core particles from Trypanosoma brucei, revealing unique histone alterations that affect DNA and protein interactions.

bioRxiv · Apr 17, 2023Biochemistry

Pore dynamics and asymmetric cargo loading in an encapsulin nanocompartment

J. Ross, Z. McIver, T. Lambert, C. Piergentili, K. J. Gallagher, J. E. Bird, F. L. Cruickshank, P. James, E. Zarazua-Arvizu, L. E. Horsfall, K. J. Waldron, M. D. Wilson, C. L. Mackay, A. Basle, D. J. Clarke, J. Marles-Wright

The paper uses cryo-EM and HDX-MS to analyze an encapsulin nanocompartment, revealing asymmetric cargo loading and dynamic pore behavior.

bioRxiv · Apr 15, 2021Biochemistry

Alternative polyadenylation is a determinant of oncogenic Ras function

A. Subramanian, M. Hall, H. Hou, M. Mufteev, B. Yu, K. E. Yuki, H. Nishimura, A. Sathaseevan, B. Lant, B. Zhai, J. Ellis, M. D. Wilson, M. Daugaard, W. B. Derry

This study shows that alternative polyadenylation regulates oncogenic Ras function by affecting transcript 3' UTR length in both C. elegans and human cells.

bioRxiv · Jun 8, 2020Cancer Biology

Retroviral integration into nucleosomes throughDNA looping and sliding along the histone octamer

M. D. Wilson, L. Renault, D. P. Maskell, M. Ghoneim, V. E. Pye, A. Nans, D. S. Rueda, P. Cherepanov, A. Costa

This study reveals that retroviral integrase uses a looping-and-sliding mechanism to reposition nucleosomal DNA for integration, similar to chromatin remodelers.

bioRxiv · Jun 7, 2019Biochemistry

Candidate cancer driver mutations in super-enhancers and long-range chromatin interaction networks

L. Wadi, L. Uuskula-Reimand, K. Isaev, S. Shuai, V. Huang, M. Liang, D. Thompson, Y. Li, L. Ruan, M. Paczkowska, M. Krassowski, I. Dzneladze, K. Kron, A. Murison, P. Mazrooei, , J. Reimand

The paper identifies 41 frequently mutated regulatory elements in cancer genomes, enriched in non-coding mutations and linked to gene expression control through chromatin interactions.

bioRxiv · Dec 19, 2017Cancer Biology