Author

V. Hargest

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:human· 3 Assay:metabolomics· 2 Research Focus:cell type annotation· 1 Organism:mouse· 1 Organism:non-human primate· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

S. Schultz-Cherry· 5 shared B. Livingston· 3 shared A. Vazquez-Pagan· 2 shared B. Sharp· 2 shared P. H. Brigleb· 2 shared R. Honce· 2 shared V. A. Meliopoulos· 2 shared V. Cortez· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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5 shared papersMicrobiology

S. Schultz-Cherry

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Diet-induced obesity impacts influenza disease severity and transmission dynamics in ferrets

V. A. Meliopoulos, R. Honce, B. Livingston, V. Hargest, P. Freiden, L. Lazure, P. H. Brigleb, E. A. Karlsson, H. Tillman, E. K. Allen, D. Boyd, P. Thomas, S. Schultz-Cherry

This study shows diet-induced obesity in ferrets increases influenza disease severity and transmission due to altered lung microenvironment and reduced antiviral responses.

bioRxiv · Sep 26, 2023 · PreprintMicrobiology

Astrovirus replication is dependent on induction of double membrane vesicles through a PI3K-dependent, LC3-independent pathway

T. Bub, V. Hargest, S. Tan, M. Smith, A. Vazquez-Pagan, T. Flerlage, P. H. Brigleb, V. A. Meliopoulos, B. D. Lindenbach, V. Cortez, J. C. Crawford, S. Schultz-Cherry

This study shows astrovirus replication depends on PI3K-dependent, LC3-independent DMV formation, suggesting PI3K as a therapeutic target for viral infections.

bioRxiv · Apr 11, 2023 · PreprintMicrobiology

Improved metabolic syndrome and timing of weight loss is crucial for influenza vaccine-induced immunity in obese mice

R. Honce, A. Vazquez-Pagan, B. Livingston, S. Cherry, V. Hargest, B. Sharp, L.-A. Van de Velde, R. C. Skinner, P. G. Thomas, S. Schultz-Cherry

This study shows pre-vaccination weight loss improves influenza vaccine efficacy in obese mice, while post-vaccination weight loss does not.

bioRxiv · Apr 16, 2022 · PreprintMicrobiology

Astrovirus Disrupts Intestinal Barrier Function by Activating Epithelial-Mesenchymal Transition

V. Hargest, G. Neale, S. Schultz-Cherry

This study shows human astrovirus infection induces epithelial-mesenchymal transition, disrupting intestinal barrier function through gene upregulation and loss of cell-cell contacts.

bioRxiv · Jun 17, 2021 · PreprintMicrobiology

Astrovirus Replication Is Inhibited by Nitazoxanide In Vitro and In Vivo

V. Hargest, B. Sharp, B. Livingston, V. Cortez, S. Schultz-Cherry

This study shows that nitazoxanide inhibits astrovirus replication in vitro and reduces viral shedding and diarrhea in vivo.

bioRxiv · Oct 8, 2019Microbiology