V. A. Meliopoulos

Maternal immunization with distinct influenza vaccine platforms elicits unique antibody profiles that impact the protection of offspring

This study compares antibody profiles from maternal influenza vaccines in mice, showing LAIV and rHA provide better offspring protection than TIV.

Diet-induced obesity impacts influenza disease severity and transmission dynamics in ferrets

This study shows diet-induced obesity in ferrets increases influenza disease severity and transmission due to altered lung microenvironment and reduced antiviral responses.

The beta 6 Integrin Negatively Regulates TLR7-Mediated Epithelial Immunity via Autophagy During Influenza A Virus Infection

This study shows that beta 6 integrin suppresses TLR7-mediated epithelial immunity during influenza A virus infection by promoting autophagy and altering TLR7 trafficking.

Host obesity impacts genetic variation in influenza A viral populations

This study investigates how host obesity affects genetic variation in influenza A virus populations using a ferret model, finding enhanced positive selection and host-specific mutations in obese hosts.

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication

This study identifies the role of G3BP1-N interaction in SARS-CoV-2 replication by showing that disrupting this interaction reduces viral replication and pathogenesis.

Astrovirus replication is dependent on induction of double membrane vesicles through a PI3K-dependent, LC3-independent pathway

This study shows astrovirus replication depends on PI3K-dependent, LC3-independent DMV formation, suggesting PI3K as a therapeutic target for viral infections.

Respiratory bacteria stabilize and promote airborne transmission of influenza A virus

This study shows that respiratory bacteria enhance the stability and transmission of influenza A virus through direct interactions.

HA stability regulates H1N1 influenza virus replication and pathogenicity in mice by modulating type I interferon responses in dendritic cells

This paper shows that a destabilizing HA mutation in H1N1 influenza virus reduces replication and pathogenicity in mice by enhancing type I interferon responses in dendritic cells.