R. Honce

Maternal immunization with distinct influenza vaccine platforms elicits unique antibody profiles that impact the protection of offspring

This study compares antibody profiles from maternal influenza vaccines in mice, showing LAIV and rHA provide better offspring protection than TIV.

Diet-induced obesity impacts influenza disease severity and transmission dynamics in ferrets

This study shows diet-induced obesity in ferrets increases influenza disease severity and transmission due to altered lung microenvironment and reduced antiviral responses.

Host obesity impacts genetic variation in influenza A viral populations

This study investigates how host obesity affects genetic variation in influenza A virus populations using a ferret model, finding enhanced positive selection and host-specific mutations in obese hosts.

An ACE2 decamer viral trap as a durable intervention solution for current and future SARS-CoV

This paper introduces an ACE2 decamer viral trap that neutralizes multiple SARS-CoV-2 variants and related coronaviruses through inhalation, showing durability and effectiveness in preclinical models.

Improved metabolic syndrome and timing of weight loss is crucial for influenza vaccine-induced immunity in obese mice

This study shows pre-vaccination weight loss improves influenza vaccine efficacy in obese mice, while post-vaccination weight loss does not.

Reduced inflammatory response and promoted multiciliated cell differentiation in mice protected by defective interfering influenza virus

This study shows that defective interfering influenza virus protects mice from viral infection by reducing inflammation and promoting multiciliated cell differentiation, independent of type I and III IFN signaling.

Influenza A virus undergoes compartmentalized replication in vivo dominated by stochastic bottlenecks

This study tracks influenza A virus diversity in ferrets, showing compartmentalized replication and stochastic bottlenecks shaping genetic diversity within lung lobes.

Efficacy of oseltamivir treatment in influenza virus infected obese mice

This study shows oseltamivir treatment does not improve viral clearance in obese mice and may increase viral genetic diversity and drug resistance.

The effects of modified sialic acids on mucus and erythrocytes on influenza A virus HA and NA functions

This study examines how modified sialic acids in mucus and erythrocytes affect influenza A virus HA and NA functions, finding that these modifications inhibit viral binding and cleavage.