P. H. Brigleb

Maternal immunization with distinct influenza vaccine platforms elicits unique antibody profiles that impact the protection of offspring

This study compares antibody profiles from maternal influenza vaccines in mice, showing LAIV and rHA provide better offspring protection than TIV.

Diet-induced obesity impacts influenza disease severity and transmission dynamics in ferrets

This study shows diet-induced obesity in ferrets increases influenza disease severity and transmission due to altered lung microenvironment and reduced antiviral responses.

The beta 6 Integrin Negatively Regulates TLR7-Mediated Epithelial Immunity via Autophagy During Influenza A Virus Infection

This study shows that beta 6 integrin suppresses TLR7-mediated epithelial immunity during influenza A virus infection by promoting autophagy and altering TLR7 trafficking.

Utility of nasal swabs for assessing mucosal immune responses towards SARS-CoV-2

This study shows nasal swabs can assess mucosal immune responses to SARS-CoV-2, revealing distinct cytokine and antibody profiles compared to systemic responses.

Astrovirus replication is dependent on induction of double membrane vesicles through a PI3K-dependent, LC3-independent pathway

This study shows astrovirus replication depends on PI3K-dependent, LC3-independent DMV formation, suggesting PI3K as a therapeutic target for viral infections.

A gut commensal protist protects against virus-mediated loss of oral tolerance

This study identifies the protist Tritrichomonas arnold as a protector against virus-induced loss of oral tolerance to gluten, showing it reduces inflammation in dendritic cells and is underrepresented in celiac disease patients.

Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasis

This study identifies NPC1 and endosomal cholesterol homeostasis as critical for reovirus penetration into the cytoplasm, but not for attachment, internalization, or disassembly.