Author

V. K. Tiwari

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 2 Microbiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:scRNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. E. Cohen· 2 shared A. S. Brewster· 2 shared D. B. Berkowitz· 2 shared D. Marchany-Rivera· 2 shared M. A. Wilson· 2 shared M. C. Thompson· 2 shared M. Dasgupta· 2 shared M. E. Wall· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

A. E. Cohen

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Author profile →

6 papers

Recent·Most cited

CNN-based learning of single-cell transcriptomes reveals a blood-detectable multi-cancer signature of brain metastasis

R. Lusby, D. Chowdhury, S. Carl, V. K. Tiwari

The paper identifies a multi-cancer gene expression signature of brain metastasis using scRNA-seq and neural networks, detectable in blood-derived platelets.

bioRxiv · Mar 8, 2024 · PreprintCancer Biology

Changes in an Enzyme Ensemble During Catalysis Observed by High Resolution XFEL Crystallography

N. Smith, M. Dasgupta, D. C. Wych, C. Dolamore, R. G. Sierra, S. Lisova, D. Marchany-Rivera, A. E. Cohen, S. Boutet, M. S. Hunter, C. Kupitz, F. Poitevin, F. R. Moss, A. S. Brewster, N. K. Sauter, , M. A. Wilson

The paper uses XFEL crystallography to observe conformational changes in an enzyme during catalysis, revealing ionization-linked dynamics that control catalytic activity.

bioRxiv · Aug 15, 2023Biochemistry

Deciphering the gene regulatory circuitry governing chemoresistance in Triple-Negative Breast Cancer

R. Lusby, A. Mariappan, Z. Zhang, V. K. Tiwari

This study identifies transcriptional regulatory networks driving chemoresistance in TNBC using single-cell transcriptome data and genetic screens.

bioRxiv · May 5, 2023 · PreprintCancer Biology

A wheat kinase and immune receptor form the host-specificity barrier against the blast fungus

S. Arora, A. Steed, R. Goddard, K. Gaurav, T. O'Hara, A. Schoen, N. Rawat, A. F. Elkot, C. Chinoy, M. H. Nicholson, S. Asuke, B. Steuernagel, G. Yu, R. Awal, M. Forner-Martinez, , P. Nicholson

The paper identifies two wheat resistance genes that act as host-specificity barriers against the blast fungus and describes assays to incorporate these genes into wheat cultivars.

bioRxiv · Jan 27, 2022Plant Biology

Mix-and-inject XFEL crystallography reveals gated conformational dynamics during enzyme catalysis

M. DasGupta, D. Budday, S. H. P. de Oliveira, P. Madzelan, D. Marchany-Rivera, J. Seravalli, B. Hayes, R. G. Sierra, S. Boutet, M. Hunter, R. Alonso-Mori, A. Batyuk, J. Wierman, A. Lyubimov, A. S. Brewster, , M. A. Wilson

This study uses mix-and-inject XFEL crystallography to observe conformational changes in isocyanide hydratase during catalysis, showing how cysteine modification affects enzyme dynamics and function.

Proceedings of the National Academy of Sciences · Dec 4, 2019Peer-reviewedBiochemistry

Antifungal effects of 3-(4-Phenyl-thiazol-2-yl)-2-thioxo-2, 3-dihydro-1H-quinazolin-4-one against Aspergillus Species

Desh D. Singh, V. K. Tiwari, Rambir Singh, G L Sharam, Rajesh Dabur

This study evaluates the antifungal activity of a new quinazoline derivative against Aspergillus species using various assays and identifies downregulated proteins in treated cultures.

bioRxiv · Oct 22, 2018 · PreprintMicrobiology