Author

V. Marusyk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:clustering· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Marusyk· 3 shared B. Desai· 3 shared D. Basanta· 2 shared E. Haura· 2 shared J. Scott· 2 shared A. C. Tan· 1 shared A. Dhawan· 1 shared A. Durmaz· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCancer Biology

A. Marusyk

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3 papers

Recent·Most cited

Peristromal niches protect lung cancers from targeted therapies through a combined effect of multiple molecular mediators

B. Desai, T. Miti, S. Prabhakaran, D. Miroshnychenko, M. Henry, V. Marusyk, C. Gatenbee, M. Bui, J. Scott, P. M. Altrock, E. Haura, A. R. A. Anderson, D. Basanta, A. Marusyk

This study shows that stromal niches protect lung cancers from ALK inhibitors through multiple mechanisms, and targeting these mechanisms together is more effective than targeting them individually.

bioRxiv · Apr 24, 2024 · PreprintCancer Biology

Understanding the Evolutionary Games in NSCLC Microenvironment

R. Bhattacharya, R. V. Velde, V. Marusyk, B. Desai, A. Kaznatcheev, A. Marusyk, D. Basanta

The paper uses evolutionary game theory to study non-cell autonomous resistance mechanisms in NSCLC, showing HGF-producing cells outcompete others and support therapy-naive cells.

bioRxiv · Nov 30, 2020 · PreprintCancer Biology

Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures

R. Vander Velde, N. Yoon, V. Marusyk, A. Durmaz, A. Dhawan, D. Myroshnychenko, D. Peral, B. Desai, O. Balynska, J. Poleszhuk, K. Liu, M. Abazeed, A. C. Tan, O. Mian, E. Haura, , A. Marusyk

The paper investigates resistance to ALK inhibitors in NSCLC, finding that resistance develops through gradual, multifactorial genetic and epigenetic changes rather than single mutations or reprogramming.

bioRxiv · Nov 19, 2019Cancer Biology