B. Desai

Peristromal niches protect lung cancers from targeted therapies through a combined effect of multiple molecular mediators

This study shows that stromal niches protect lung cancers from ALK inhibitors through multiple mechanisms, and targeting these mechanisms together is more effective than targeting them individually.

Evolutionary double-bind treatment using radiotherapy and NK cell-based immunotherapy in prostate cancer

This study combines radiotherapy and NK cell immunotherapy to exploit an evolutionary double-bind strategy in prostate cancer, showing that RT-resistant cells become more vulnerable to NK cell killing.

Understanding the Evolutionary Games in NSCLC Microenvironment

The paper uses evolutionary game theory to study non-cell autonomous resistance mechanisms in NSCLC, showing HGF-producing cells outcompete others and support therapy-naive cells.

Antifragile therapy

This paper introduces a mathematical framework to quantify cancer cell line fragility or antifragility to treatment variability and applies it to treatment resistance and collateral sensitivity.

Neuronal Hyperexcitability is a DLK-dependent Trigger of HSV-1 Reactivation that can be Induced by IL-1

This study shows that neuronal hyperexcitability, induced by IL-1β, triggers HSV-1 reactivation through DLK/JNK pathway and histone phosphorylation.

Anti-tumor effects of an Id antagonist with no acquired resistance

This study demonstrates that AGX51, an Id antagonist, effectively inhibits tumor growth in multiple cancer models without inducing acquired resistance.

Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures

The paper investigates resistance to ALK inhibitors in NSCLC, finding that resistance develops through gradual, multifactorial genetic and epigenetic changes rather than single mutations or reprogramming.

The Pipeline for Digital Analysis of IHC Images from NSCLC Xenograft Tissues

The paper evaluates the impact of stromal protection on Alectinib resistance using IHC images from NSCLC xenograft tissues analyzed with QuPath.