Author

V. P. O'Brien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:imaging· 1

Frequent Co-Authors

N. R. Salama· 3 shared C. Leverich· 2 shared J. Dubrulle· 2 shared A. E. R. Martinez· 1 shared A. E. Rodriguez Martinez· 1 shared A. Koehne· 1 shared A. Rodriguez· 1 shared C. C. Yeung· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMicrobiology

N. R. Salama

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Single-cell profiling uncovers a Muc4-expressing metaplastic gastric cell type sustained by Helicobacter pylori-specific inflammation

V. P. O'Brien, Y. Kang, M. K. Shenoy, G. Finak, W. C. Young, J. Dubrulle, L. Koch, A. E. R. Martinez, J. A. Snow, J. Williams, E. Donato, S. K. Batra, C. C. Yeung, S. Bullman, M. A. Koch, , N. R. Salama

The paper identifies a Muc4-expressing metaplastic gastric cell type in mice driven by H. pylori inflammation and shows its association with proliferation in human gastric cancer.

bioRxiv · Dec 20, 2022 · PreprintMicrobiology

Helicobacter pylori chronic infection selects for effective colonizers of metaplastic glands

V. P. O'Brien, L. K. Jackson, J. Frick, A. E. Rodriguez Martinez, D. S. Jones, C. D. Johnston, N. R. Salama

The paper shows that H. pylori strains from later stages of infection are better at colonizing metaplastic gastric tissue, linked to genetic variation in the sabB gene.

bioRxiv · Jun 13, 2022Microbiology

Helicobacter pylori accelerates KRAS-dependent gastric dysplasia

V. P. O'Brien, A. Koehne, J. Dubrulle, A. Rodriguez, C. Leverich, P. Kong, J. Campbell, R. Pierce, J. Goldenring, E. Choi, N. Salama

This study shows that Helicobacter pylori infection accelerates KRAS-driven gastric dysplasia in mice by promoting inflammation, altering gene expression, and increasing proliferation of preneoplastic glands.

bioRxiv · Oct 6, 2020Cancer Biology

Non-helical Helicobacter pylori show altered gland colonization and elicit less gastric pathology during chronic infection

L. E. Martinez, V. P. O'Brien, C. Leverich, S. E. Knoblaugh, N. R. Salama

This study compares the colonization and pathogenicity of helical and straight rod Helicobacter pylori strains in mice, finding that straight rods show reduced inflammation during chronic infection.

bioRxiv · Dec 26, 2018Microbiology