E. M. Walker

LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes

This study identifies LONP1's role in mitochondrial protein folding and shows its impact on beta cell survival and hyperglycemia in type 2 diabetes.

Species-specific roles for the MAFA and MAFB transcription factors in regulatingislet β cell identity

The paper investigates the species-specific roles of MAFA and MAFB in maintaining β cell identity, showing MafA in mice and MAFB in humans repress non-β cell hormones like GAST.

Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues

This study shows that mitochondrial dysfunction triggers a retrograde signaling program that reduces cellular maturity in metabolic tissues, and blocking this signaling can restore cell identity and improve hyperglycemia.

Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation state

This study identifies heterogeneous α-cell dysfunction in type 2 diabetes linked to impaired maturation and electrophysiological changes.

Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis

This study shows that Mitofusin 1 and 2 regulate mitochondrial DNA content, which is critical for glucose homeostasis in beta-cells, independent of mitochondrial structure.