T. Mandrup-Poulsen

Tipping-point transition from transient to persistent inflammation in pancreatic islets

This paper uses a computational model to show that pancreatic islets can switch between transient and persistent inflammation modes based on feedback loops and islet size.

Circadian desynchronization desensitizes insulin-producing cells to cytokine-mediated transcriptomic remodeling and cell death: a novel beta-cell anti-apoptotic response to inflammation

This study shows that circadian desynchronization protects insulin-producing cells from cytokine-induced transcriptomic changes and cell death by modulating NF-κB signaling and clock gene regulation.

Proinflammatory Cytokines Suppress Nonsense-Mediated RNA Decay to Impair Regulated Transcript Isoform Processing in Pancreatic β-Cells

This study shows proinflammatory cytokines suppress NMD activity in β-cells by downregulating UPF3B, leading to increased alternative splicing and ECM-related gene expression, which contributes to β-cell dysfunction.

A blunted GPR183/oxysterol axis during dysglycemia results in delayed recruitment of macrophages to the lung during M. tuberculosis infection

This study shows that dysglycemia impairs the GPR183/oxysterol axis, leading to delayed macrophage recruitment and worsened tuberculosis outcomes in mice.

GPR183 regulates interferons and bacterial growth during Mycobacterium tuberculosis infection: interaction with type 2 diabetes and TB disease severity

Mitophagy protects beta cells from inflammatory damage in diabetes

This study shows mitophagy protects beta cells from inflammatory damage in diabetes by reducing mitochondrial dysfunction and cell death.

The connexin 43 regulator Rotigaptide reduces cytokine-induced cell death in human islets

Rotigaptide reduces cytokine-induced cell death in human islets, with some protection observed even in Cx43-deficient cells through mechanisms independent of gap-junction coupling.