ApoA-I Protects Pancreatic β-cells from Cholesterol-induced Mitochondrial Damage and Restores their Ability to Secrete Insulin
B. Manandhar, E. Pandzic, N. Deshpande, S.-Y. Chen, V. Wasinger, M. Kockx, E. N. Glaros, K. L. Ong, S. R. Thomas, M. Wilkins, R. Whan, B. J. Cochran, K.-A. Rye
This study shows apoA-I improves β-cell insulin secretion by reducing oxidative stress and enhancing mitochondrial function in cholesterol-loaded cells.
bioRxiv · Apr 3, 2023Cell Biology