M. Wilkins

ATP13A3 Variants Promote Pulmonary Arterial Hypertension by Disrupting Polyamine Transport

This study identifies ATP13A3 as a polyamine transporter whose deficiency leads to endothelial dysfunction and pulmonary arterial hypertension.

Polymer biodegradation by Halanaerobium promotes reservoir souring during hydraulic fracturing.

The paper investigates how Halanaerobium metabolizes guar gum in produced water from hydraulic fracturing, showing that polymer biodegradation at 30°C generates fermentation intermediates that contribute to reservoir souring when introduced into subsurface environments at 60°C.

ApoA-I Protects Pancreatic β-cells from Cholesterol-induced Mitochondrial Damage and Restores their Ability to Secrete Insulin

This study shows apoA-I improves β-cell insulin secretion by reducing oxidative stress and enhancing mitochondrial function in cholesterol-loaded cells.

Effect of insulin insufficiency on ultrastructure and function in skeletal muscle

This study investigates how insulin deficiency affects skeletal muscle structure and function in mice with beta-cell dysfunction, finding that insulin supplementation restores muscle integrity and gene expression.

PTPN1 deficiency modulates BMPR2 signaling and induces endothelial dysfunction in Pulmonary Arterial Hypertension

This study identifies PTPN1 as a regulator of BMPR2 signaling in PAH, showing its downregulation in PAH patients and link to endothelial dysfunction.