Author

Vanessa Grau

Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Jorge P. FerreriD· 3 shared Miguel Angel Maestro· 3 shared Andrew Tym HattersleyiD· 1 shared Anthony BeucheriD· 1 shared Edgar BernardoiD· 1 shared Elisa De FrancoiD· 1 shared Eva Cristina VaqueroiD· 1 shared Francisco X. RealiD· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersGenomics

Jorge P. FerrerORCID

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3 papers

Recent·Most cited

Hnf1b-CreER causes efficient recombination of a Rosa26-RFP reporter in duct and islet δ cells

Meritxell Rovira, Miguel Angel Maestro, Vanessa Grau, Jorge P. Ferrer

The paper evaluates the Hnf1b-CreERT2 reporter system in adult pancreatic duct and δ cells, finding high recombination efficiency in duct cells but low in β cells and partial activation in δ cells.

Islets · Jul 20, 2021Peer-reviewedDevelopmental Biology

Neonatal diabetes mutations disrupt a chromatin pioneering function that activates the human insulin gene

İldem Akerman, Miguel Angel Maestro, Elisa De Franco, Vanessa Grau, Sarah Elizabeth Flanagan, Javier García-Hurtado, Gerhard Mittler, Philippe Ravassard, Lorenzo Piemonti, Sian Ellard, Andrew Tym Hattersley, Jorge P. Ferrer

The paper shows that a mutation associated with neonatal diabetes disrupts chromatin activation of the insulin gene in human cells.

Cell Reports · Apr 1, 2021Peer-reviewedGenomics

HNF1A recruits UTX to activate a differentiation program that suppresses pancreatic cancer

Mark Kalisz, Edgar Bernardo, Anthony Beucher, Miguel Angel Maestro, Natalia del Pozo, I.R. Hernández Millán, Lena Häberle, Martin Schlensog, Sami Alexander Safi, Wolfram Trudo Knoefel, Vanessa Grau, Matías G. De Vas, Karl B. Shpargel, Eva Cristina Vaquero, Terry Magnuson, , Jorge P. Ferrer

This study shows HNF1A recruits UTX to activate a differentiation program that suppresses pancreatic cancer by remodeling enhancers and inhibiting oncogenic pathways.

The EMBO Journal · Mar 10, 2020Peer-reviewedGenomics