Antigen-specific CD8 T cells are generated and reactivated in the bone marrow following viral brain infections and impact the bone marrow niche
Delaney M. Wolf, Kelly M. Hotchkiss, Rachael Ann Reesman, Christian Karl Pfaller, Eliese Moelker, Alexandra M. Hoyt-Miggelbrink, Cori E. Fain, Kathryn E. Blethen, Pamela K. Norberg, Shannon E. Wallace, Vatsal Jain, Gerald Arthur Grant, Mustafa Khasraw, Vidyalakshmi Chandramohan, Aaron J. Johnson, Katayoun Ayasoufi
This study shows that virus-specific CD8 T cells are generated and reactivated in the bone marrow after brain viral infections, leading to changes in the bone marrow niche.
bioRxiv · Dec 26, 2025 · PreprintImmunology