Author

Eliese Moelker

Duke UniversityORCID 0009-0004-0708-366XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:flow cytometry· 1 Organism:human· 1 Assay:multiome· 1

Frequent Co-Authors

Katayoun AyasoufiiD· 3 shared Kelly M. HotchkissiD· 3 shared Bhairavy J. PuviindraniD· 2 shared John Howard SampsoniD· 2 shared Mustafa KhasrawiD· 2 shared Pamela K. Norberg· 2 shared Peter Edward FecciiD· 2 shared Sarah L. CookiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersImmunology

Katayoun AyasoufiORCID

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3 papers

Recent·Most cited

IL-12 Secreting CAR-T Cells Reprogram the Tumor Microenvironment and Improve Efficacy Against Heterogeneous Models of Glioblastoma

Steven Shen, Aditya A Mohan, Kelly M. Hotchkiss, Sarah L. Cook, Kisha Patel, Eliese Moelker, Bhairavy J. Puviindran, Ariel T Gonzalez, Saïf Eddine Zaidi, Samantha E. Spellicy, Adam Schwartz, Carter M. Suryadevara, Daniel Wilkinson, Katayoun Ayasoufi, Peter Edward Fecci, , Anoop P. Patel

This study shows that IL-12-secreting CAR-T cells improve glioblastoma treatment by enhancing T-cell persistence and reprogramming the tumor microenvironment without lymphodepletion.

Journal for ImmunoTherapy of Cancer · Mar 1, 2026Peer-reviewedImmunology

Antigen-specific CD8 T cells are generated and reactivated in the bone marrow following viral brain infections and impact the bone marrow niche

Delaney M. Wolf, Kelly M. Hotchkiss, Rachael Ann Reesman, Christian Karl Pfaller, Eliese Moelker, Alexandra M. Hoyt-Miggelbrink, Cori E. Fain, Kathryn E. Blethen, Pamela K. Norberg, Shannon E. Wallace, Vatsal Jain, Gerald Arthur Grant, Mustafa Khasraw, Vidyalakshmi Chandramohan, Aaron J. Johnson, Katayoun Ayasoufi

This study shows that virus-specific CD8 T cells are generated and reactivated in the bone marrow after brain viral infections, leading to changes in the bone marrow niche.

bioRxiv · Dec 26, 2025 · PreprintImmunology

IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models

Kirit Singh, Kelly M. Hotchkiss, Sarah L. Cook, Pamy Noldner, Ying Zhou, Eliese Moelker, Chelsea O. Railton, Emily E. Blandford, Bhairavy J. Puviindran, Shannon E. Wallace, Pamela K. Norberg, Gary E. Archer, Beth H. Shaz, Katayoun Ayasoufi, John Howard Sampson, , Peter Edward Fecci

This study shows that IL-7-expanded autologous lymphocytes increase VLA-4 expression and accumulate in glioblastoma tumors, enhancing the effectiveness of T cell-based therapies.

Journal of Clinical Investigation · Apr 17, 2025Peer-reviewedCancer Biology