Synthetic genomes unveil the effects of synonymous recoding
Ákos Nyerges, Anush Chiappino-Pepe, Bogdan Budnik, Maximilien S. Baas-Thomas, Regan Flynn, Shirui Yan, Nili Ostrov, Min Liu, Meizhou Wang, Qingmei Zheng, Fangxiang Hu, Kangming Chen, Alexandra Rudolph, Xi Dawn Chen, Jenny J. Ahn, , George McDonald Church
This study uses synthetic genomes to investigate how synonymous codon recoding affects organismal fitness and develops a workflow to overcome lethal effects of codon swaps.
bioRxiv · Jun 16, 2024 · PreprintSynthetic Biology