Helicase-deficient TFIIH causes severe disease features via persistent DNA excision without damage removal
David Häckes, Arjan F. Theil, Geun Hoe Kim, Y. J. Kim, Paula J. van der Meer, Céline Van Wassenhove, Qing Yu, Karen L. Thijssen, Anja Raams, Vera van Buren, Wim Vermeulen, Martijn S. Luijsterburg, Jurgen A. F. Marteijn, Jun‐Hyuk Choi, Hannes Lans
The paper shows that helicase-deficient TFIIH causes severe disease by trapping DNA in a futile repair cycle, leading to persistent excision without lesion removal.
bioRxiv · Sep 11, 2026 · PreprintGenetics