Catabolism of extracellular glutathione supplies amino acids to support tumor growth
Fábio Hecht, Marco Zocchi, Emily T. Tuttle, Nathan P. Ward, Fatemeh Alimohammadi, A. M. Zakaria Khan, Veronica C. Gomes, Bradley Smith, Jennifer J. Twardowski, Bradley N. Mills, Kevin A. Welle, Sina Ghaemmaghami, Zhuoran Zhou, Yuhan Gan, Yun Pyo Kang, , Isaac S. Harris
This study shows that extracellular glutathione supports tumor growth by providing amino acids through catabolism, and inhibiting this process slows tumor growth.
Nature · Mar 18, 2026Peer-reviewedCancer Biology