SIRT6 loss causes intervertebral disc degeneration in mice by promoting senescence and SASP status
Pranay L. Ramteke, Bahiyah Watson, Mallory Toci, Victoria A. Tran, Shira N. Johnston, Maria Tsingas, Ruteja A. Barve, Ramkrishna Mitra, Richard F. Loeser, John A. Collins, Makarand V. Risbud
This study shows that SIRT6 loss in mice leads to intervertebral disc degeneration by promoting senescence and SASP through changes in histone modifications, DNA accessibility, and autophagy.
bioRxiv · Sep 9, 2024 · PreprintMolecular Biology