Author

Maria Tsingas

Thomas Jefferson UniversityORCID 0000-0003-3859-6236Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:ATAC-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Makarand V. RisbudiD· 3 shared Ruteja A. BarveiD· 2 shared Shira N. JohnstoniD· 2 shared Aaron R. GoldmaniD· 1 shared Bahiyah WatsoniD· 1 shared John A. Collins· 1 shared Konstantinos TsingasiD· 1 shared Mallory TociiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCell Biology

Makarand V. RisbudORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintFeb 24, 2025

Lactate metabolic coupling between the endplates and nucleus pulposus via MCT1 is essential for intervertebral disc health

Maria Tsingas, Konstantinos Tsingas, Wujuan Zhang…·Makarand V. Risbud

This study shows that lactate transfer via MCT1 between nucleus pulposus and endplate cells is essential for intervertebral disc health, as its absence leads to degeneration.

3 citations

mousespatial transcriptomics

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Molecular BiologybioRxivPreprintSep 9, 2024

SIRT6 loss causes intervertebral disc degeneration in mice by promoting senescence and SASP status

Pranay L. Ramteke, Bahiyah Watson, Mallory Toci…·Makarand V. Risbud

This study shows that SIRT6 loss in mice leads to intervertebral disc degeneration by promoting senescence and SASP through changes in histone modifications, DNA accessibility, and autophagy.

1 citation

mousebulk RNA-seq

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Cell BiologyFrontiers in Cell and Developmental BiologyPeer-reviewedMar 6, 2024

Increased HIF-2α Activity in the Nucleus Pulposus Causes Intervertebral Disc Degeneration in the Aging Mouse Spine

Shira N. Johnston, Maria Tsingas, Rahatul Ain…·Makarand V. Risbud

This study shows that increased HIF-2α activity in nucleus pulposus cells accelerates intervertebral disc degeneration in aging mice.

6 citations

mouseproteomics

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