Author

Mallory Toci

Thomas Jefferson UniversityORCID 0009-0002-7490-2528Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:ATAC-seq· 2 Assay:bulk RNA-seq· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Bahiyah WatsoniD· 2 shared John A. Collins· 2 shared Makarand V. RisbudiD· 2 shared Pranay L. RamtekeiD· 2 shared Ramkrishna MitraiD· 2 shared Ruteja A. BarveiD· 2 shared Maria TsingasiD· 1 shared Oliver AbinaderiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersBiochemistry

Bahiyah WatsonORCID

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2 papers

Recent·Most cited

SIRT6 Activation Improves Intervertebral Disc Health in the Aging Spine

Pranay L. Ramteke, Bahiyah Watson, Sanjana Jagannath, Sarah Elizabeth Bell, Mallory Toci, Olivia K. Ottone, Qinglin Wu, Oliver Abinader, Ramkrishna Mitra, John A. Collins, Ruteja A. Barve, Makarand V. Risbud

This study shows that activating SIRT6 with MDL-800 improves intervertebral disc health in aged mice by enhancing autophagy, reducing senescence, and improving matrix quality.

bioRxiv · Mar 5, 2026 · PreprintBiochemistry

SIRT6 loss causes intervertebral disc degeneration in mice by promoting senescence and SASP status

Pranay L. Ramteke, Bahiyah Watson, Mallory Toci, Victoria A. Tran, Shira N. Johnston, Maria Tsingas, Ruteja A. Barve, Ramkrishna Mitra, Richard F. Loeser, John A. Collins, Makarand V. Risbud

This study shows that SIRT6 loss in mice leads to intervertebral disc degeneration by promoting senescence and SASP through changes in histone modifications, DNA accessibility, and autophagy.

bioRxiv · Sep 9, 2024 · PreprintMolecular Biology